Respiratory syncytial virus infection enhances airway hyperresponsiveness in guinea pigs and the underlined mechanism.
- Author:
Li-Ping FANG
1
;
Hao-Wen QI
;
Han-Jun LIN
;
Shu-Jun LI
;
Dong-Liang XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asthma; immunology; physiopathology; virology; Bronchial Hyperreactivity; immunology; physiopathology; virology; Female; Guinea Pigs; Male; Ovalbumin; immunology; Random Allocation; Receptor, Muscarinic M2; physiology; Respiratory Syncytial Virus Infections; immunology; Respiratory Syncytial Viruses; immunology
- From: Chinese Journal of Applied Physiology 2009;25(1):121-124
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the relation between Respiratory Syncytial Virus infection and asthma development by measuring airway responsiveness (AR) and M2R function.
METHODSGuinea pigs (n = 34) were randomly divided into 4 groups: Hep-2/NS group (group A, n = 9), RSV/NS group (group B, n =9), Hep-2/OVA group (group C, n = 8) and RSV/OVA group(group D, n = 8). On day 21 after infection we tested AR and M2R. Then counted eosinophils in BALF and observed pathological change.
RESULTSIntraairway pressure(IP mmH20) of group B had no significant difference with group A(P > 0.01), and the extent of IP decrease also had no difference between groups A and B (P > 0. 05), but IP of C group were much higher than group A (P<0.05), with extent of IP decrease lower than group A (P < 0.05). And IP of group D were higher than group C (P < 0.01), with the extent of IP decrease much lower than group C (P < 0.05).
CONCLUSIONRSV infection could enhance OVA-induced M2R dysfunction, then develop AHR.
