Advances in genes and molecular markers of pheochromocytoma.
- Author:
Shi-kun GONG
1
;
Zhong LIU
1
Author Information
1. Department of Cardiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China.
- Publication Type:Journal Article
- MeSH:
Adrenal Gland Neoplasms;
genetics;
Biomarkers, Tumor;
genetics;
Humans;
Mutation;
Pheochromocytoma;
genetics
- From:
Journal of Zhejiang University. Medical sciences
2014;43(2):227-233
- CountryChina
- Language:Chinese
-
Abstract:
Pheochromocytoma is a tumor derived from chromaffin tissue in the adrenergic system with excessive secretion of catecholamine.Pheochromocytoma occurs at any age of patients,commonly in 40-60 years,and the incidence is slightly higher in women than in men.In recent years,studies have shown that the mutations of von Hippel-Lindau gene (VHL),rearranged during transfection gene (RET),neurofibromatosis type 1 gene (NF-1),succinate dehydrogenase gene (SDH),transmembrane protein 127 gene (TMEM127),myelocytomatosis oncogene-associated factor X gene (MAX) are associated with pheochromocytoma.Immunohistochemical studies have revealed that a number of molecular markers,such as telomerase,vascular endothelial growth factor,cyclooxygenase-2,adrenomedullin,plasma chromaffin protein A,signal transducer and activator of transcription-3 are of value in identification of tumor origin,its biological behaviors and differentiation of pheochromocytoma. This article reviews the newest research progresses in molecular biology of pheochromocytoma.
