Research advances on the roles of nicotinamide phosphoribosyltransferase in inflammation.
- Author:
Jing HUANG
1
,
2
;
Er-qing WEI
1
;
Yun-bi LU
1
;
Author Information
1. Department of Pharmacology, Zhejiang University School of Medicine
2. Key Laboratory of Medical Neurobiology of Ministry of Health, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Inflammation;
enzymology;
Nicotinamide Phosphoribosyltransferase;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2014;43(2):234-239
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide phosphoribosyltransferase (Nampt) is also called visfatin or pre-B-cell colony-enhancing factor. The functions of Nampt have been reported as a cytokine, an adipokine and the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis. As a pleiotropic multifunctional protein, Nampt is involved in a variety of physiological and pathological conditions including innate immunity, metabolic disorders, and stress; and Nampt also participates in inflammatory disorders such as acute lung injury, atherosclerosis, myocardial infarct, obesity, type 2 diabetes, and rheumatoid arthritis. The studies indicate that Nampt might be a potential target for pharmacological intervention against inflammatory diseases. We review research advances on the roles of Nampt in inflammation.
