Whole-genome sequencing: a new approach for understanding of pathogenesis and individualized treatment of cancer.
- Author:
Yingqiu PAN
1
;
Wei ZHANG
;
Shuqing CHEN
Author Information
1. Taizhou Hospital Affiliated of Wenzhou Medical College, Linhai, China.
- Publication Type:Journal Article
- MeSH:
Genome, Human;
genetics;
Humans;
Neoplasms;
genetics;
therapy;
Precision Medicine;
Sequence Analysis, DNA;
methods
- From:
Journal of Zhejiang University. Medical sciences
2013;42(1):103-108
- CountryChina
- Language:Chinese
-
Abstract:
With the development of sequencing technology, the cost of whole-genome sequencing was significantly declined.Meanwhile, with the application of combined whole-genome sequencing with epigenetic analysis on methylation and histone acetylation, the comprehensive and systematic analysis of numerous samples became a reality and we are able to re-understand the genesis and development of cancer. New ideas are emerging in comparative genomics research methods, from comparison of genomes among different individuals to horizontal self-comparison of different tissues and vertical self-comparison of genomes recently.Individualized diagnosis and treatment of cancer has shown a bright future.
