AQP4 regulation for cerebral edema.
- Author:
Min LI
1
;
Shaojun CHEN
;
Xuequn CHEN
;
Jizeng DU
Author Information
1. Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Aquaporin 4;
metabolism;
physiology;
Brain;
metabolism;
physiopathology;
Brain Edema;
metabolism;
physiopathology;
Homeostasis;
Humans;
Water-Electrolyte Balance;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2013;42(1):114-122
- CountryChina
- Language:Chinese
-
Abstract:
Water balance is one of the basic regulation mechanisms of homeostasis. There are 13 subtypes of aquaporins in mammals (AQP0-AQP12). In neural system, the AQP4 is mainly distributed in astrocytes. Phosphorylation and expression regulation of AQP4 is involved in the formation of brain edema, particularly in the clearance of vasogenic edema and the formation of cytotoxic edema. This article reviews regulations and functions of AQP4 in vasogenic edema and cytotoxic edema.
