p53-independent signaling pathway in DNA damage-induced cell apoptosis.
- Author:
Xiaoyun ZHANG
1
;
Ying JIANG
;
Jun YANG
Author Information
1. Zhejiang University School of Public Health, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
genetics;
DNA Damage;
Humans;
Signal Transduction;
Tumor Suppressor Protein p53;
genetics;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2013;42(2):217-223
- CountryChina
- Language:Chinese
-
Abstract:
p53 is considered as the "master regulator" in DNA damage-induced cell apoptosis. However, p53 is the most frequently mutated gene in human cancers (more than 50 %). Thus the research of p53-independent pathway in cell apoptosis may ultimately provide new therapeutic opportunities for many cancers. It has been shown that Caspase 2, p73, p63, and NF-kappa B-related signaling pathways are involved in DNA damage-induced, p53-independent cell apoptosis. This article reviews the recent research progress in these signaling pathways.
