Protective effects of carnosine against closed head injury in mice.
- Author:
Xuying PEI
1
;
Kangxin NI
;
You ZHOU
;
Kun YING
;
Xiangnan ZHANG
;
Xuyun LI
;
Yuan LU
;
Zhong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carnosine; therapeutic use; Disease Models, Animal; Head Injuries, Closed; drug therapy; pathology; Male; Mice; Mice, Inbred ICR
- From: Journal of Zhejiang University. Medical sciences 2013;42(3):291-296
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of carnosine against experimental closed head injury (CHI) in mice.
METHODSThe CHI model was established by free-falling weight-drop. Carnosine (250 mg/kg or 500 mg/kg) was administered intraperitoneally 30 min before brain trauma, then q.d for 7 d; while normal saline was administrated for control group. The neurological defect was evaluated by neurological severity score (NSS) within 7 d; the survival rate and the histological alternations were observed.
RESULTSCarnosine prevented the body weight loss of mice at dose of 500 mg/kg; significantly increased the survival rate, and reduced the neurological defect and histological damage at dose of 250 and 500 mg/kg.
CONCLUSIONCarnosine can attenuate closed head injury in mice.
