Role of G protein-coupled receptor 17 in central nervous system injury.
- Author:
Zhuang ZHANG
1
;
Erqing WEI
;
Yunbi LU
Author Information
1. Key Laboratory of Medical Neurobiology of Ministry of Health, Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Central Nervous System;
injuries;
physiopathology;
Humans;
Neurogenesis;
physiology;
Receptors, G-Protein-Coupled;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2013;42(3):355-359
- CountryChina
- Language:Chinese
-
Abstract:
G-protein-coupled receptor 17 (GPR17), an originally orphan receptor, was identified as a new uracil nucleotides/cysteinyl leukotriene receptor. However, whether GPR17 is really classified as a leukotriene receptor is a matter deserving further investigation. GPR17 is involved in many physiological and pathological processes including brain injury, spinal cord injury, and oligodendrocyte differentiation. GPR17 may become a new therapeutic target in these diseases. In this article, the research progress on the pharmacology and pathophysiological roles of GPR17 is reviewed.
