Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy.
- Author:
Weibo LIU
1
;
Hualiang YU
;
Biao JIANG
;
Leilei ZHENG
;
Shaohua YU
;
Bing PAN
;
Risheng YU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aspartic Acid; analogs & derivatives; metabolism; Case-Control Studies; Creatine; metabolism; Depressive Disorder; metabolism; physiopathology; Female; Hippocampus; metabolism; Humans; Inositol; metabolism; Magnetic Resonance Spectroscopy; Male; Memory; Neuropsychological Tests; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2013;42(4):450-455
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation of neurochemical metabolism in hippocampus with memory function in young adult patients with first-episode depression.
METHODSTwenty patients with first-episode depression (patient group) and fifteen health subjects (control group) were enrolled in the study. The neurochemical metabolism, including the levels of N-acetylaspartate (NAA), Choline (Cho), Creatine (Cr), Myoinositol (mI) were measured by proton magnetic resonance spectroscope (1H-MRS) in bilateral hippocampus. Wechsler Memory Scale (WMS) were used to examine the memory function in both groups.
RESULTSThe memory quotient (89.15 ±6.62) of patient group was significantly lower than that of controls (P <0.01),the scores of long-term memory,short-term memory and immediate memory in patients were also lower than those of controls (P<0.05 or 0.01). In patient group, the ratio of NAA/Cr (1.34 ±0.08) in the left hippocampus was significantly lower than that of control group (P<0.01); and the ratio of mI/Cr in the bilateral hippocampus [(0.63 ±0.13) in left and (0.6 ±0.1) in right] was significantly higher than those in control group (P<0.05). In patient group,the ratio of NAA/Cr in the left hippocampus was positively correlated with WMS scores (P<0.01), and the ratio of mI/Cr in the left hippocampus was negatively correlated with WMS scores (P<0.05).
CONCLUSIONThe memory deficit and abnormal metabolism function of neuron cell in hippocampus coexist in young adult patients with first-episode depression, and the lower NAA/Cr and higher mI/Cr ratio in the left hippocampus may result in the memory deficit.