From endoplasmic reticulum to Golgi apparatus: a secretory pathway controlled by signal molecules.
- Author:
Jiasheng WANG
1
;
Jianhong LUO
;
Xiaomin ZHANG
Author Information
1. Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Endoplasmic Reticulum;
metabolism;
Golgi Apparatus;
metabolism;
Humans;
Protein Transport;
physiology;
Secretory Pathway;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2013;42(4):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Protein transport from endoplasmic reticulum (ER) to Golgi apparatus has long been known to be a central process for protein quality control and sorting. Recent studies have revealed that a large number of signal molecules are involved in regulation of membrane trafficking through ER, ER-Golgi intermediate compartment and Golgi apparatus. These molecules can significantly change the transport rate of proteins by regulating vesicle budding and fusion. Protein transport from ER to Golgi apparatus is not only controlled by signal pathways triggered from outside the cell, it is also regulated by feedback signals from the transport pathway.
