Crosstalk between canonical TGF-β/Smad and Wnt/β-catenin signaling pathway.
- Author:
Cui RAO
1
;
Shan-Li LIN
;
Huan WEN
;
Hong DENG
Author Information
1. Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Fibrosis;
metabolism;
Humans;
Neoplasms;
metabolism;
Signal Transduction;
Transforming Growth Factor beta;
physiology;
Wnt Proteins;
physiology;
Wnt Signaling Pathway
- From:
Journal of Zhejiang University. Medical sciences
2013;42(5):591-596
- CountryChina
- Language:Chinese
-
Abstract:
TGF-β signaling pathway plays a central role in the signaling networks that control the growth, differentiation of the cell, and the initiation of fibrosis and cancer. Wnt signaling pathway is critical for the embryonic development and the invasion and migration of cancer cells. TGF-β signaling and Wnt signaling, both of which play an important role in regulating embryonic development, fibrotic disease and tumor progression, have a close relationship. Researches find several typical cross points between these two signaling systems, such as Smad, Axin, Dvl and β-catenin. In this review, we focus on the crosstalk between TGF-β signaling and Wnt signaling through these typical factors, intending to better understand the process of fibrosis and tumor progression.
