Effects of chrysalis oil on learning, memory and oxidative stress in D-galactose-induced ageing model of mice.
- Author:
Weiping CHEN
1
;
Qiongjie YANG
;
Xing WEI
Author Information
- Publication Type:Journal Article
- MeSH: Aging; Animals; Bombyx; chemistry; Galactose; toxicity; Learning; drug effects; Male; Memory; drug effects; Mice; Mice, Inbred ICR; Oxidative Stress; drug effects
- From: Journal of Zhejiang University. Medical sciences 2013;42(6):620-624
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of chrysalis oil on learning, memory and oxidative stress in D-galactose-induced ageing model of mice.
METHODSMice were injected intraperitoneally with D-galactose daily and received chrysalis oil intragastrically simultaneously for 30 d. Then mice underwent space navigation test and spatial probe test, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) contents in mouse brain were measured.
RESULTSCompared to model group, escape latency in mice treated with 6 ml/kg*d chrysalis oil was significantly shorter (P<0.05), crossing times in 12 ml/kg*d group and 6 ml/kg*d group treated with chrysalis oil were significantly increased (P<0.05). Chrysalis oil treatment (12ml/kg*d) significantly increased SOD and GSH-PX activity and reduced MDA contents in brain of D-galactose-induced aging mice.
CONCLUSIONChrysalis oil can improve the ability of learning and memory in D-galactose-induced aging mice, and inhibit peroxidation in brain tissue.
