Clinical research of xinganbao capsule on the treatment of chronic hepatitis B liver fibrosis.
- Author:
Xian-Bo WANG
1
;
Yu-Yong JIANG
;
Cai-Yan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Drugs, Chinese Herbal; therapeutic use; Female; Hepatitis B, Chronic; drug therapy; pathology; Humans; Liver Cirrhosis; drug therapy; pathology; Male; Middle Aged; Phytotherapy; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2012;32(3):325-328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of Xinganbao Capsule (Cordyceps Sinensis) on the chronic hepatitis B liver fibrosis.
METHODSSixty patients with chronic hepatitis B were randomly assigned to the trail group (40 cases) and the control group (20 cases). The trail group was treated with Xinganbao Capsule, 8 capsules each time, three times a day. The control group was given Heluo Shugan Tablet, 5 pills each time, thrice daily. Six months consisted of one therapeutic course. The liver function, four indicators of serum fibrosis, liver histology, and other items were detected.
RESULTSXinganbao Capsule could reduce serum ALT and AST levels, serum HA, PC-III and LN levels (all P<0.05), showing statistical difference when compared with before treatment. The HA and LN levels decreased more significantly in the control group when compared with before treatment (P<0.05). Totally 21 patients (53% of the recruited cases) in the trial group completed the liver biopsy twice. After treated with Xinganbao Capsule, 81% patients (17/21) had decreased liver inflammation 1 grade or more, 52% patients (11/21) had decreased fibrosis staging one or more, and 33% (7/21) patients had no change in fibrosis.
CONCLUSIONXinganbao Capsule could improve the liver function, reduce liver inflammation, and fight against hepatic fibrosis.
