Literature research of the hepatotoxicity of glucoside tripterygium total and its synergism and toxicity reducing effects.
- Author:
Hong-Gang LI
1
;
Wei JI
;
Jian-Ming SU
Author Information
1. Department of Comprehensive Internal Medicine, Zhuzhou Fist Hospital of Hunan Province, Hunan 412000.
- Publication Type:Journal Article
- MeSH:
Animals;
Chemical and Drug Induced Liver Injury;
Drug Interactions;
Glucosides;
pharmacology;
toxicity;
Liver;
drug effects;
Tripterygium
- From:
Chinese Journal of Integrated Traditional and Western Medicine
2012;32(3):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Correlated literatures of the liver injury induced by glucoside tripterygium total (GTT) and of its synergism and toxicity reducing effects were retrieved to study the correlation between the dosage, the time point of GTT and the liver injury. The monomer or active ingredients of animals and plants with the hepatoprotective effect were included. The mechanisms of action between GTT and these drugs were analyzed. The mechanism for GTT induced liver injury and its synergism and toxicity reducing mechanisms, as well as the preventive measures were discussed, thus providing evidence-based basis for safe clinical application of GTT.
