Study on amplification of ZNF217 in primary gastric carcinoma.
- Author:
Ya-qing ZHU
1
;
Zheng-gang ZHU
;
Bing-ya LIU
;
Xue-hua CHEN
;
Yi ZHANG
;
Hao-ran YIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; DNA, Neoplasm; genetics; Female; Gene Amplification; Humans; Male; Middle Aged; Stomach Neoplasms; genetics; Trans-Activators; genetics
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.
METHODSSemiquantitative polymerase chain reaction (PCR) was used to determine DNA copies of ZNF217 in the specimens from forty- seven cases with primary gastric carcinoma.
RESULTSThere was no difference in DNA copies between tumor specimens and paratumor normal tissues. The incidence of ZNF217 amplification was 11.36% in gastric cancer. The amplification of ZNF217 was significantly associated with tumor size(P< 0.01) and intestinal type of stomach cancer(P< 0.05).
CONCLUSIONOncogene ZNF217 may play a role in specific tumor types or subtypes of gastric cancer. There may be other oncogenes associated with gastric carcinoma in 20(q)13.
