Liver transplantation in patients with fulminant hepatitis B: experience in Canton, China.
- Author:
Xiaofeng ZHU
1
;
Guihua CHEN
;
Xiaoshun HE
;
Minqiang LU
;
Guodong WANG
;
Changjie CAI
;
Yang YANG
;
Jiefu HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Hepatic Encephalopathy; drug therapy; etiology; surgery; Hepatitis B; complications; drug therapy; surgery; Humans; Lamivudine; therapeutic use; Liver Transplantation; Male; Middle Aged; Recurrence; Survival Rate
- From: Chinese Medical Sciences Journal 2002;17(1):44-46
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China.
PATIENTS AND METHODSTen patients with fulminant hepatitis B received orthotopic liver transplantation under veno-venous bypass. All patients had preoperatively serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro-hemorrhage. RUSULT: Seven of the 10 patients have survived for 3 approximately 18 months, but 3 died of multi-organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3 approximately 18 months without the signs of recurrence of hepatitis B.
CONCLUSIONOrthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.
