The efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer.
- Author:
Shuqin WANG
1
;
Wei LIU
;
Yuhua WANG
;
Baoe ZHAI
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Lung Cancer 2002;5(4):290-292
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo evaluate the efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer.
METHODSFifty patients in group A received the L/FUDR-EP regimen, while 42 patients in group B were given the L/FEP regimen. The response and toxicity were evaluated after three courses of treatment.
RESULTSThe therapeutic response of group A and group B were 40.0% and 38.1% respectively (P > 0.05). The toxicities such as marrow inhibition, gastrointestinal symptoms, alopecia and local phlebitis were remarkably lower in group A than those of group B (P < 0.01).
CONCLUSIONSThe FUDR based regimen is effective to the advanced NSCLC, and its toxicity is lower than 5-FU.
