BACKGROUNDTo study the methods for monitoring nephrotoxicity of cisplatin in lung cancer chemotherapy.

METHODSThe serum urea nitrogen (BUN), creatine (Cr) and urine β2-microglobulin ( β2-MG),α1-microglobulin(α1-MG), albumin (Alb), transferrin (TRF), and retinol-binding-protein (RBP) were measured dynamically in 61 patients with lung cancer who received high-dose chemotherapy with DDP (80- 120 mg/m2) (totally 114 cycles), and some indexes of early nephrotxcity were screened.

RESULTSAt the early stage of chemotherapy (d1-5), the abnormal rates of urine β2-MG and α1-MG were much more predominant than those of other indexes (P < 0.001). The abnormal rates of serum BUN and Cr were increased significantly in the late period of chemotherapy (d10). There were abnormal elevation of urine β2-MG and/or α1-MG at the early stage of chemotherapy for the patients whose serum BUN and creatine were all abnormal at the late stage.

CONCLUSIONSThe urine β2-MG and /or α1-MG might be the valuable indexes for early diagnosis of nephrotoxicity in lung cancer chemotherapy with cisplatin.