Comparison of efficacy and toxicity between gemcitabine plus carboplatin and gemcitabine plus cisplatin in the treatment of advanced non-small cell lung cancer.
- Author:
Xiaohong CAI
1
;
Ping CHEN
;
Xude YIN
;
Qiu LI
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Lung Cancer 2002;5(6):427-428
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo observe the efficacy and toxicity of gemcitabine plus carboplatin (GCarb) versus gemcitabine plus cisplatin (GCis) in the treatment of advanced non-small cell lung cancer (NSCLC).
METHODSForty patients with histologically confirmed NSCLC were randomized to enter the study. GCarb group:Gemcitabine 1 000 mg/m² IV on day 1,8; carboplatin AUC 4-6 IV on day 1. GCis group: Gemcitabine 1 000 mg/m² IV on day 1,8; cisplatin 30-40 mg/m² IV on day 1-3.
RESULTSThe response rate was 65% and 60% for GCarb group and GCis group respectively (P > 0.5). Toxicities included myelosuppression, digestive reaction, alopecia and rash. Digestive toxicity in GCarb group was less than that in GCis group (P < 0.05).
CONCLUSIONSBoth GCarb and GCis regimes can be used as first-line protocol in the chemotherapy of non small cell lung cancer.
