- Author:
Kun WANG
1
;
Yu'e SUN
;
Tao WANG
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Lung Cancer 2002;5(6):451-453
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the correlation between the intensity of facilitative glucose transporter(GLUT1) expression and prognosis in stage I and II non-small cell lung cancer (NSCLC).
METHODSEighty-seven specimens were immunohistochemically stained using an antibody against GLUT1 antigen, and the intensity of GLUT1 expression was assessed by computer image analysis system in NSCLC with pathologic stage I and II.
RESULTSEighty-one cases of NSCLC (93.1%) were GLUT1 positive. The intensity of GLUT1 expression (optic density) was significantly higher in lymph node metastasis positive group than that in negative group ( 0.340 7 ±0.070 3 vs 0.276 5±0.082 4, P < 0.05). The patients with high GLUT1 expression ( > 0.298 1 ) had significantly lower survival time than those with low GLUT1 expression (≤ 0.298 1 )(P < 0.05 ).
CONCLUSIONSGLUT1 is closely correlated with the prognosis of NSCLC patients in stage I and II.