Pharmaceutical characteristics of brucine stealth liposomes.
- Author:
Jun CHEN
1
;
Wei WANG
;
Bao-chang CAI
;
Wei HU
;
Li-jie WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Stability; Drugs, Chinese Herbal; chemistry; pharmacokinetics; Liposomes; chemistry; pharmacokinetics; Particle Size; Rats; Strychnine; analogs & derivatives; chemistry; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2008;33(17):2100-2104
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes.
METHODBrucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively.
RESULTThe encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes.
CONCLUSIONAs the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.
