An investigation on formation mechanisms and preparation of curcumin phospholipid complex.
- Author:
An-chang LIU
1
;
Li-xia ZHAO
;
Guang-xi ZHAI
;
Hong-xiang LOU
;
Jing-shan DU
Author Information
1. Qilu Hospital of Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Curcuma;
chemistry;
Drugs, Chinese Herbal;
chemistry;
Phospholipids;
chemistry
- From:
China Journal of Chinese Materia Medica
2008;33(17):2112-2117
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to investigate the preparation and characteristics of curcumin phospholipid complex, including the effects of reaction time, reaction solvent, reaction concentration and reaction temperature. Preparation technology resulted in that 0.5 g curcumin and 10 g soy phospholipid dissolved in 100 mL anhydrous alcohol, were stirred 1 h in 50 degrees C waterbath, then steamed alcohol in decompression, collected solid residue and vacuum dried for 12 h. The physicochemical properties for the new complex including IR spectrometer, mass spectrograph and HNMR equipment were detected. As a result, the formation of the complex is based on the reaction between phospholipid polar group rounding phosphorus atom and curcumin. This result gave the evidence for the formation mechanism of phospholipid complex.
