Promoting effect of constituents in plasma after oral administration of liuwei dihuangwan on proliferation of rat osteoblast.
- Author:
Hui SUN
1
;
Ning ZHANG
;
Li-jing LI
;
Xi-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Cell Proliferation; drug effects; Cells, Cultured; Drugs, Chinese Herbal; administration & dosage; Glucosides; blood; Glycosides; blood; Iridoid Glucosides; Iridoids; blood; Osteoblasts; cytology; drug effects; Plasma; chemistry; drug effects; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2008;33(17):2161-2164
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elucidate the promoting effect of the constituents in plasma after oral administration of Liuwei Dihuangwan on proliferation of rat osteoblast.
METHODTo add the constituents in plasma after oral administration of Liuwei Dihuangwan with rational concentration into culture solution of rat osteoblast, later using MT method for determining the proliferation rate of rat osteoblast.
RESULTThe Mixed group including morroniside, sweroside and loganin with different dose all significantly promoted proliferation of rat osteoblast.
CONCLUSIONThis study preliminarily elucidated the constituents such as morroniside, sweroside and loganin in plasma after oral administration of Liuwei Dihuangwan were main biological constituents which contributed to anti-osteoporosis bioactivity of Liuwei Dihuangwan.
