Studies on bioactive constituents of whole herbs of Vernonia cinerea.
- Author:
Hua-xu ZHU
1
;
Yu-ping TANG
;
Lin-mei PAN
;
Zhi-da MIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; chemistry; Glucosides; chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; PC12 Cells; Polycyclic Compounds; chemistry; pharmacology; Rats; Stigmasterol; analogs & derivatives; chemistry; Vernonia; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(16):1986-1988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model.
METHODThe constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.
RESULTFour compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated.
CONCLUSIONCompounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity.
