Forecast on shelf life of Chinese Angelica based on its chemical components variation.
- Author:
Jing-jing XIE
1
;
Jing ZHAO
;
Shao-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Drug Stability; Drug Storage; Drugs, Chinese Herbal; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(16):1997-2001
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo predict the shelf life of Chinese Angelica by investigating the stability of its active components.
METHODThe classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica.
RESULTThe correlation equations, thermal constant at ambient temperature (k(25 degrees C)) and shelf life (t(0.9)) for coniferyl ferulate and Z-Ligustilide were lgk = -5152. 1/T + 13.8 (r = 0.9985), 3. 33 x 10(-4), 13 d and lgk = -4064.6/T + 10.4 (r = 0.9997), 5.91 x 10(-4), 7 d, respectively.
CONCLUSIONThe shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.
