Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response.

Author: Jun-chao CHEN ¹ ; You-jun PAN ; Xing-shan LI ; Jie SUN ; Hong-xia LIU ; Rui-yuan SUN ; Qing-shan ZHENG
Author Information

1. Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Publication Type:Journal Article
MeSH: Animals; Computer Simulation; Drug Interactions; Pharmacology; methods; Rats
From: China Journal of Chinese Materia Medica 2008;33(16):2029-2033
CountryChina
Language:Chinese
Abstract:
OBJECTIVEAn approach is set up to calculate pharmacodynamic interaction and simulate the combined response.
METHODAn orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots.
RESULTThis approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination.
CONCLUSIONThe approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.