The Recurrence of Seizure due to Decreased Valproic Acid Level after Administration of Carbapenem.
- Author:
Dong Gun KIM
1
;
Ok Joon KIM
Author Information
1. Department of Neurology, College of Medicine, Pochon CHA University, Seongnam, Korea. okjun77@cha.ac.kr, okjun77@hanmail.net
- Publication Type:Case Report
- Keywords:
Valproic acid;
Panipenem-betamipron;
Seizure
- MeSH:
Acinetobacter baumannii;
Humans;
Male;
Middle Aged;
Persistent Vegetative State;
Pneumonia;
Recurrence*;
Seizures*;
Valproic Acid*
- From:Journal of Korean Epilepsy Society
2007;11(1):64-66
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Valproic acid (VPA) is one of the most commonly used antiepileptic drug, but has many drug-drug interactions. A 58-year-old male under the vegetative state has been well controlled with valproic acid (VPA) monotherapy without seizure attacks during the last 6 months. Pneumonia developed and panipenem-betamipron (PAPM-BP) for acinetobacter baumannii was administered. Seizure attacks recurred after 12 days of initiating PAPM-BP. During the maintenance period of PAPM-BP, serum level of VPA was decreased. After the cessation of PAPM-BP, serum level of VPA increased to the previous level without further seizure attacks. PAPM-BP should be cautiously used together with VPA because of possible drug-drug interaction.
