Plasma thromboxane A2 and prostaglandin I2 levels and their ratio in children with Henoch-Schonlein purpura nephritis.
- Author:
Xue-Yun LU
1
;
Huan-Yun YANG
;
Qiao-Zhi YANG
;
Jun LIANG
;
Yan-Ping ZHU
;
Sheng-Ying DONG
;
Wen-Ying SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Epoprostenol; blood; Female; Humans; Male; Nephritis; blood; Purpura, Schoenlein-Henoch; blood; Thromboxane A2; blood
- From: Chinese Journal of Contemporary Pediatrics 2008;10(3):343-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes and roles of plasma thromboxane A2 (TXA2) and prostaglandin I2 (PGT2) levels and their ratio in Henoch-Schonlein purpura nephritis (HSPN) in children.
METHODSPlasma levels of TXA2 and PGI2 were measured using ELISA in 45 children with HSPN and 20 healthy children.
RESULTSPlasma TXA2 level was significantly higher, while plasma PGI2 level was significantly lower in HSPN children in the acute phase than in the control (P<0.01). The ratio of TXA2/PGI2 in HSPN children in the acute phase was statistically higher than in the control (9.55+/-3.56 vs 0.87+/-0.21; P<0.01). In the convalescence phase, plasma TXA2 level remained higher and plasma PGI2 level was elevated and higher than in the control, so the ratio of TXA2/PGI2 was reduced to normal level.
CONCLUSIONSThe imbalance of TXA2 and PGI2 may be involved in the development of renal damage in children with HSPN. The balance of TXA2 and PGI2 contributes to renal recovery.
