Combination of rabbit antithymocyte globulin and cyclosporine A as first-line therapy for adult severe aplastic anemia.
- Author:
Hui-min CAO
1
;
Hui-jun WANG
;
Li ZHANG
;
Li-ping JING
;
Kang ZHOU
;
Dong-lin YANG
;
Hong-qiang LI
;
Qing-guo LIU
;
Zhang-song YAN
;
Yong-ze LIU
;
Yu-hong WU
;
Yu-Lin CHU
;
Feng-kui ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Anemia, Aplastic; drug therapy; Animals; Antilymphocyte Serum; therapeutic use; Cyclosporine; therapeutic use; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; therapeutic use; Male; Middle Aged; Rabbits; Retrospective Studies; Treatment Outcome; Young Adult
- From: Chinese Journal of Hematology 2011;32(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the efficacy and side-effects of combination of rabbit antithymocyte globulin (ATG) and cyclosporine A (CsA) as the first-line immunosuppressive therapy (IST) for adult severe aplastic anemia (SAA) patients.
METHODSAdult SAA or very severe aplastic anemia (VSAA) patients treated with rabbit ATG + CsA as first line therapy in our hospital from 2003 to 2008 were retrospectively analysed and the therapeutic response relevant factors were analysed.
RESULTSSeventy-nine patients were enrolled. Of all these patients, 6 died within 3 months after IST. The overall response rate was 82.2% and the median time to transfusion independent was 60 days. The therapeutic response rate in 32 SAA patients (100%) was significantly higher than that in 41 VSAA cases (68.3%) (P = 0.001). Patients with neutrophil response to G-CSF treatment had a higher IST response rate than those without response to G-CSF (100% vs 67.5%, P = 0.001). Sixty-one patients (77.2%) occurred serum sickness reaction. Three patients relapsed and two developed clonal hematological abnormalities after IST. The 3-year overall survival for all the patients was 88.9%.
CONCLUSIONSRabbit ATG in combination with CsA as first-line IST for adult SAA can lead to excellent treatment outcomes with minor adverse effects.