Twelve benzene derivatives from Clausena excavata.
- Author:
Wen-Wen PENG
;
Wei-Wu SONG
;
Mao-Bo HUANG
;
Guang-Zhi ZENG
;
Ning-Hua TAN
- Publication Type:Journal Article
- MeSH:
Benzene Derivatives;
chemistry;
Candida albicans;
drug effects;
Cell Line, Tumor;
Clausena;
chemistry;
HeLa Cells;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Plant Leaves;
chemistry;
Plant Roots;
chemistry;
Plant Stems;
chemistry;
Staphylococcus aureus;
drug effects
- From:
Acta Pharmaceutica Sinica
2014;49(12):1689-1693
- CountryChina
- Language:English
-
Abstract:
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
