Histone deacetylase 6: structure, functions and development of selective inhibitors.
- Author:
Ren-shuai LIU
;
Hao FANG
- Publication Type:Journal Article
- MeSH:
Histone Deacetylase Inhibitors;
pharmacology;
Histone Deacetylases;
chemistry;
Humans;
Substrate Specificity
- From:
Acta Pharmaceutica Sinica
2015;50(1):7-14
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylase 6 (HDAC6) is an unique subtype of histone deacetylases with two tandem deacetylase domains and substrate specificity for non-histone proteins. It is involved in many important physiological and pathological processes and has become a promising therapeutic target in recent decades. Different kinds of potent HDAC6-selective inhibitors have been reported around the world. This paper reviews the progress in the study of structure and functions of HDAC6 as well as the development of HDAC6-selective inhibitors.
