A novel citrinin derivative from the marine-source fungus Penicillium citrinum.
- Author:
Min NI
;
Wei-Ling LIN
;
Peng YANG
;
Shui-Chun MAO
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemistry;
isolation & purification;
Citrinin;
analogs & derivatives;
chemistry;
isolation & purification;
HL-60 Cells;
Humans;
Magnetic Resonance Spectroscopy;
Penicillium;
chemistry
- From:
Acta Pharmaceutica Sinica
2015;50(2):203-206
- CountryChina
- Language:English
-
Abstract:
A novel citrinin derivative, penicitrinol L (1), along with two known analogues, penidicitrinin B (2) and pennicitrinone A (3) were isolated from the marine-source fungus Penicillium citrinum. The structure of the new compound was elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis. Furthermore, compound 1 showed modest cytotoxic activity against HL-60 cell line and compound 3 showed weak cytotoxic activity against A375 cell line.
