Farnesoid X receptor regulates glucose and lipid metabolisms.
- Author:
Qian JIANG
;
Jun PENG
;
Shuai-nan LIU
;
Zhu-fang SHEN
- Publication Type:Journal Article
- MeSH:
Bile Acids and Salts;
Diabetes Mellitus, Type 2;
Glucose;
metabolism;
Homeostasis;
Humans;
Lipid Metabolism;
Receptors, Cytoplasmic and Nuclear;
metabolism
- From:
Acta Pharmaceutica Sinica
2015;50(3):245-251
- CountryChina
- Language:Chinese
-
Abstract:
As a member of nuclear receptor superfamily, farnesoid X receptor (FXR) has been shown to regulate numerous metabolic pathways, which include playing an important role in bile acid metabolism, maintaining lipid and glucose homeostasis when FXR is activated. With the prevalence of the glucose and lipids disorder, FXR attracts increasing attention. It may be a potential target for the treatment of type 2 diabetes mellitus and lipid disorders.
