Research progress of p70 ribosomal protein S6 kinase inhibitors.
- Author:
Zhi-jun TU
;
Gao-yun HU
;
Qian-bin LI
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
Humans;
Protein Kinase Inhibitors;
chemistry;
Ribosomal Protein S6 Kinases, 70-kDa;
antagonists & inhibitors;
metabolism;
Signal Transduction;
TOR Serine-Threonine Kinases
- From:
Acta Pharmaceutica Sinica
2015;50(3):261-271
- CountryChina
- Language:Chinese
-
Abstract:
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade. The p70 ribosomal protein S6 kinase is closely associated with diverse cellular processes such as protein synthesis, mRNA processing, glucose homeostasis, cell growth and apoptosis. Recent studies have highlighted the important role of S6K in cancer, which arose interests of scientific researchers for the design and discovery of anti-cancer agents. Herein, the mechanisms of S6K and available inhibitors are reviewed.
