The mechanism of rosiglitazone compound based on network pharmacology.
- Author:
Yu BAI
;
Xue-mei FAN
;
Han SUN
;
Yi-ming WANG
;
Qiong-lin LIANG
;
Guo-an LUO
- Publication Type:Journal Article
- MeSH:
Calcium Signaling;
Cognitive Dysfunction;
Computational Biology;
Diabetes Mellitus;
Humans;
Pharmacology;
methods;
Thiazolidinediones;
pharmacology
- From:
Acta Pharmaceutica Sinica
2015;50(3):284-290
- CountryChina
- Language:Chinese
-
Abstract:
Applications of network pharmacology are increasingly widespread and methods abound in the field of drug development and pharmacological research. In this study, we choose rosiglitazone compound as the object to predict the targets and to discuss the mechanism based on three kinds of prediction methods of network pharmacology. Comparison of the prediction result has identified that the three kinds of prediction methods had their own characteristics: targets and pathways predicted were not in accordance with each other. However, the calcium signaling pathway could be predicted in the three kinds of methods, which associated with diabetes and cognitive impairment caused by diabetes by bioinformatics analysis. The above conclusion indicates that the calcium signaling pathway is important in signal pathway regulation of rosiglitazone compound, which provides a clue to further explain the mechanism of the compound and also provides a reference for the selection and application of methods of network pharmacology in the actual research.
