Poly(β-amino esters)-based barriers for tumor targeted delivery system.
- Author:
Wei-nan LI
;
Qi XU
;
Yan-hong WANG
;
Da-wei CHEN
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemistry;
Drug Carriers;
chemistry;
Drug Delivery Systems;
Esters;
chemistry;
Hydrogen-Ion Concentration;
Neoplasms;
drug therapy;
Polymers
- From:
Acta Pharmaceutica Sinica
2015;50(4):434-439
- CountryChina
- Language:Chinese
-
Abstract:
Poly(β-amino esters) (PBAE) are used for drug carrier and have many advantages, such as pH-sensitivity, low toxicity, structural diversity and the synthetic method of PBAE is easy. Therefore they are possessed broad application prospect in tumor-targeted drugs delivery systems. In this paper, the structural features and target drugs delivery property of PBAE are reviewed. The application forms of PBAE and different anti-cancer drugs loaded in the copolymer for tumor-targeted drugs delivery systems are introduced particularly.
