Progress in the study of near-infrared fluorescent probes for the detection of β-amyloid deposition in Alzheimer's disease.
- Author:
Lei DU
;
Hai-wei FENG
;
Yu-yan LI
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
diagnosis;
Amyloid beta-Peptides;
analysis;
Fluorescence;
Fluorescent Dyes;
Humans;
Molecular Probes;
Positron-Emission Tomography;
Spectroscopy, Near-Infrared;
Tomography, Emission-Computed, Single-Photon
- From:
Acta Pharmaceutica Sinica
2015;50(5):528-534
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is the most common cause of cognitive impairment in older people. With the aging of society is more and more serious, AD caused great burden to patients and society. A β is a classical biomarker of AD, which has been widely used in clinical diagnosis of AD patients. Compared with positron emission tomography (PET) and single photon emission computed tomography (SPECT), near infrared fluorescence imaging has many advantages including highly sensitive, non-invasive, safety and inexpensive. Therefore, many research groups have focused on developing the molecular probes of near-infrared fluorescence (NIRF) imaging. In this article, we will review the progress of the probes of NIRF.
