Preparation and performance characterization of electrospun drug loaded poly (vinyl alcohol)/chitosan nanofibrous membrane.
- Author:
Yani ZHANG
1
;
Shanwei WU
;
Jiayao XU
;
Wei CHEN
;
Yuanyuan LV
Author Information
- Publication Type:Journal Article
- MeSH: Chitosan; chemical synthesis; Drug Carriers; Membranes, Artificial; Nanofibers; Polyvinyl Alcohol; chemical synthesis
- From: Journal of Zhejiang University. Medical sciences 2013;42(6):644-648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare nanofibrous membranes of poly (vinyl alcohol)/chitosan (PVA/CS) loaded with varied salvianic acid A sodium (SAS) contents.
METHODSUltrafine fiber mats were prepared with PVA/CS as matrix and SAS as model drug. The structure and morphology of the nanofibrous membranes were characterized by FT-IR and SEM. Drug-loading amount and drug release profiles of these membranes were determined by UV VIS spectra, and the degradation of the membranes was also investigated.
RESULTSAverage diameters of PVA/CS/SAS nanofibers with different SAS contents were 280 ≊390 nm. Drug-loading amount of these nanofibrous membranes was high and exhibited sustained and controlled release behavior for SAS.
CONCLUSIONThe PVA/CS/SAS nanofibrous membrane prepared in this study loads drug uniformly and has remarkably sustained release behavior, which may offer strategies for the research and development of novel topical drug delivery systems.
