Progress on neuroprotective effects of erythropoietin.
- Author:
Xin LIU
1
;
Haiqin WU
Author Information
1. Department of Neurology, The Second Affiliated Hospital,Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
- Publication Type:Journal Article
- MeSH:
Erythropoietin;
metabolism;
physiology;
Humans;
Neurophysiology;
Neuroprotective Agents;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2013;42(6):693-699
- CountryChina
- Language:Chinese
-
Abstract:
The function of erythropoietin (EPO) is recognized as a stimulator for proliferation of red blood cell (RBC), however,recent studies have showed that EPO and EPO-R are widely distributed in nervous system, which indicates that it may also have important functions in nervous system. Studies proved its neuroprotective effects, especially in ischemic-hypoxic nerve tissues. These effects are mainly activated through several signal transduction pathway downstream and multiple mechanisms are involved. As a neuroprotective factor, EPO has been investigated in the clinical studies, which may lead to the clinical application in the future.
