Nicotinamide phosphoribosyltransferase and its roles in cancer.
- Author:
Xiao-fang XU
1
;
Ming WU
2
Author Information
1. Department of Thoracic Surgery,Zhejiang Cancer Hospital,Hangzhou 310022,China.
2. Department of Thoracic Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Neoplasms;
enzymology;
Nicotinamide Phosphoribosyltransferase;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2014;43(1):109-114
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells. Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor, induces B-cell differentiation, inhibits neutrophil apoptosis, and affects immune and inflammatory functions. This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.
