Twenty-Year Single Surgeon Experience with Radical Perineal Prostatectomy: Oncologic, Functional Outcomes and Perioperative Complications.
10.22465/kjuo.2016.14.3.144
- Author:
Joon Hyung PARK
1
;
Sang Eun LEE
;
Young Hyo CHOI
;
Wan SONG
;
Han Yong CHOI
Author Information
1. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hanyong.choi@samsung.com
- Publication Type:Original Article
- Keywords:
Prostatic neoplasms;
Oncologic outcomes;
Complications;
Radical perineal prostatectomy
- MeSH:
Classification;
Follow-Up Studies;
Humans;
Passive Cutaneous Anaphylaxis;
Postoperative Complications;
Prostate;
Prostate-Specific Antigen;
Prostatectomy*;
Prostatic Neoplasms;
Recurrence;
Retrospective Studies;
Wounds and Injuries
- From:Korean Journal of Urological Oncology
2016;14(3):144-151
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate oncologic, functional outcomes and complications in patients with prostate cancer (PCa) who underwent radical perineal prostatectomy (RPP). MATERIALS AND METHODS: A retrospective review of patients who underwent RPP by a single surgeon between 1995 and 2014 was performed. We analyze clinicopathologic characteristics and postoperative complications including urinary continence and erectile function. Kaplan-Meier survival analysis was used to access biochemical recurrence (BCR)-free survival (BFS) and cancer-specific survival (CSS) and log-rank test was applied. Complications were stratified by the Clavien-Dindo classification system. RESULTS: A total of 816 patients were included in this study. The mean prostate-specific antigen and prostate volume was 8.89 ng/mL and 30.8 mL. Positive surgical margin was identified in 174 patients (21.3%) after RPP. During a mean follow-up of 58.7 months, 173 patients (21.2%) experienced BCR. Overall, 44 patients (5.4%) died, of which 15 (1.8%) died from PCa. The 5-year BFS in patients with T2, T3a, and T3b were 84.8%, 69.7%, and 46.7% (p<0.001), respectively. The 10-year CSS in patients with same groups were 98.9%, 98.2%, and 79.5% (p<0.001), respectively. At 12 months after RPP, recovery of urinary continence and erectile function was identified in 88.3% and 63.7% of patients. Wound dehiscence (8.9%) was the most common complication. However, approximately 78% of complications were grade I or II. CONCLUSIONS: Our study indicates that RPP shows acceptable outcomes in terms of oncologic results and complications in patients with PCa. Careful attention is required to prevent wound dehiscence.
