Immune function of interleukin-33 and its relation to human diseases.
- Author:
Bi-jun CUI
1
;
Qing-qing WANG
1
Author Information
1. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
immunology;
Humans;
Inflammation;
immunology;
Interleukin-33;
Interleukins;
immunology
- From:
Journal of Zhejiang University. Medical sciences
2014;43(3):366-371
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family expressed in a wide range of organs and cells. IL-33 is a dual-functional molecule: as a classical cytokine it induces immune response and it also regulates gene transcription in the nucleus. Altered expression of IL-33 has been observed in various human diseases such as inflammation, autoimmune diseases, and virus infection. The article reviews advances on immune function of IL-33 and its relation to a variety of human diseases.
