Research advances on immunoregulation and anti-inflammation function of mesenchymal stem cells and their application in treatment of renal diseases.
- Author:
Jian ZHANG
1
;
Zheng-yan ZHAO
1
Author Information
1. Affiliated Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Kidney Diseases;
Mesenchymal Stromal Cells;
immunology
- From:
Journal of Zhejiang University. Medical sciences
2014;43(3):372-378
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cell (MSC) can differentiate into multiple lines in various tissues. MSC has the advantage of congenital hypoimmunogenicity and can interact with both innate and adaptive immunocytes, exerting immunoregulatory function via direct cell-cell contact and secreting soluble factors. It also can migrate to tissue injury sites to dampen inflammatory reactions. MSC can be potentially applied to treat immunological and inflammatory diseases, such as acute renal injury, immune kidney diseases, diabetic nephropathy and end-stage renal diseases. This review summarizes the biological characteristics of MSC and the prospects of its application in treatment of renal diseases.
