Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer.
- Author:
Shu-qing JIN
1
;
Yu-fei PU
1
;
Ying QIU
2
;
Katsuyuki AOZASA
3
;
Eiichi MORII
3
Author Information
- Publication Type:Journal Article
- MeSH: Adenosine Triphosphatases; metabolism; Adult; Aged; Carcinoma, Non-Small-Cell Lung; diagnosis; metabolism; Cell Cycle Proteins; metabolism; Female; Homeodomain Proteins; metabolism; Humans; Lung Neoplasms; diagnosis; metabolism; Male; Middle Aged; Prognosis; Proto-Oncogene Proteins; metabolism; Transcription Factors; metabolism; Valosin Containing Protein
- From: Journal of Zhejiang University. Medical sciences 2014;43(4):413-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between pre B cell leukemia transcription factor 2 (PBX2)/Ets domain transcription factor 2 (ELF2) expression with prognosis of non-small cell lung cancer (NSCLC).
METHODSExpressions of ELF2 and PBX2 were examined in 206 patients of NSCLC by immunohistochemistry. The correlation of PBX2/ELF2 expression with valosin-containing protein (VCP) expression and clinicopathologic factors of NSCLC patients was analyzed. Chi-square test, Fisher's exact test and Cox's regression were used for statistical analysis.
RESULTSThe level of PBX2/ELF2 expression was associated with VCP expression (P=0.0126). Univariate analysis showed that 5-y disease free survival and overall survival (OS) of NSCLC were correlated with expression of PBX2, PBX2/ELF2 and VCP, tumor size, histological differentiation, visceral pleural invasion, N and T in pTNM grades, and clinical stages (P<0.05). The 5-y OS was also related to vascular invasion (P=0.0322). Multivariate analysis revealed that the expression level of PBX2/ELF2 and histological differentiation were independent predictors for NSCLC.
CONCLUSIONThe level of PBX2/ELF2 expression is related to VCP expression, indicating that PBX2/ELF2-VCP pathway may be associated with the prognosis of NSCLC patients.
