Relationship between IL-18 gene polymorphism and unexplained recurrent spontaneous abortion.

Dan Wang; Chen Wang; Ling-zhi Zheng; Min Zhu; Yi-min Zhu

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Relationship between IL-18 gene polymorphism and unexplained recurrent spontaneous abortion.

Author: Dan WANG ^{1
,

2} ; Chen WANG ³ ; Ling-zhi ZHENG ³ ; Min ZHU ³ ; Yi-min ZHU ⁴
Author Information

1. Department of Reproduction, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
2. Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
3. Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
4. Department of Reproduction, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Publication Type:Journal Article
MeSH: Abortion, Habitual; genetics; Adult; Female; Genetic Predisposition to Disease; Humans; Interleukin-18; genetics; Polymorphism, Genetic; Young Adult
From: Journal of Zhejiang University. Medical sciences 2014;43(4):448-452
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the association between IL-18 polymorphisms and the risk of unexplained recurrent spontaneous abortion (URSA).
METHODSThe polymorphism of rs187238, rs360718 and rs360717 in IL-18 was determined by PCR in combination with DNA sequencing in 207 patients with URSA and 144 women with normal pregnancy.
RESULTSThe frequency of gene types GG, GC+CC of rs187238 (-137 G/C) in URSA group and control group was 77.3%, 22.7%, and 95.8%, 4.2%, respectively (χ²=22.767, P<0.001). The frequency of allele C in URSA group was significantly higher than that in control groups (13.04% vs 2.1%, χ²=26.102, P<0.001) . The risk of spontaneous abortion in C allele carriers was 7.050 times higher than that in G allele carriers (OR=7.050, 95%CI: 2.990-16.622). No significant difference in genotype frequency and allele frequency of rs360718 and rs360717 polymorphism was noticed between URSA group and control group (χ²=1.497, P=0.221; χ²=0.858, P=0.354).
CONCLUSIONGC+CC genotype and C allele of Rs187238 in IL-18 gene are associated with the susceptibility of recurrent spontaneous miscarriage. Rs360718 and rs360717 in IL-18 may not be associated with URSA.