Fourier transform infrared spectroscopy in detection of breast cancer.
- Author:
Su-han CHEN
1
;
Wei-wei LAO
1
;
Zao-xian XU
1
;
Qing LIU
2
;
Huan WEN
1
;
Hong DENG
1
Author Information
1. Zhejiang University School of Medicine, Hangzhou 310058, China.
2. Institute of Analytical Chemistry and Applied Chemistry of Zhejiang University, Hangzhou 310027, China.
- Publication Type:Journal Article
- MeSH:
Breast Neoplasms;
diagnosis;
Female;
Humans;
Spectroscopy, Fourier Transform Infrared
- From:
Journal of Zhejiang University. Medical sciences
2014;43(4):494-500
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the most common cancer in women. Later diagnosis of the disease is the leading cause of poor prognosis. Fourier-transform infrared (FTIR) spectroscopy is a novel approach to provide information about the molecular components and metabolic conditions of human tissue; therefore it can detect the early changes caused by cancer cells prior to histological manifestation. FTIR-based diagnosis is rapid, simple and label free, which meets the requirements of an automated and patient-friendly technique. The current article gives an overview of the experimental techniques, data analysis methods and spectral signatures of breast cancer in FTIR-based diagnosis, summarizes the present challenges by focusing on the history of FTIR spectroscopy in breast cancer since 1990s, and highlights some investigations that give a perspective of FTIR-based diagnosis.
