Progress on genetic basis of primary aldosteronism.
- Author:
Hong ZHANG
1
;
Wei GU
1
;
Min-yue JIA
1
Author Information
1. Department of Endocrinology，Second Affiliated Hospital，Zhejiang University School of Medicine，Hangzhou 310009，China.
- Publication Type:Journal Article
- MeSH:
Cytochrome P-450 CYP11B2;
genetics;
Humans;
Hyperaldosteronism;
genetics;
Mutation;
Polymorphism, Genetic;
Steroid 11-beta-Hydroxylase;
genetics
- From:
Journal of Zhejiang University. Medical sciences
2014;43(5):612-618
- CountryChina
- Language:Chinese
-
Abstract:
It has been proven that familial aldosteronism type I is related to 11-beta hydroxylase (CYP11B1)/aldosterone synthase (CYP11B2) chimeric genes. In recent years, accumulated evidences indicate that the genetic basis of primary aldosteronism may involve chromosome 7p22 candidate genes, polymorphisms of CYP11B1 and CYP11B2 genes, mutations of ion channel- related KCNJ5, ATP1A1, CACNA1D genes. The article reviews the progress on genetic basis of primary aldosteronism.
