Experimental study on preventive effect of Yougui drink on femoral head necrosis in rats under micro CT.
- Author:
Xing-chao SHEN
;
Cai-yuan SONG
;
Shuai-jie LYU
;
Hang-xing BAO
;
Pei-jian TONG
;
Lu-wei XIAO
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Bone Density; Drugs, Chinese Herbal; therapeutic use; Femur Head Necrosis; diagnostic imaging; pathology; prevention & control; Rats; Rats, Sprague-Dawley; X-Ray Microtomography; methods
- From: China Journal of Orthopaedics and Traumatology 2015;28(12):1106-1110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the preventive effect of Yougui drink on femoral head necrosis in rats under micro CT.
METHODSTwenty-five SD rats were divided into steroid hormone group (group A, 10 rats ), Yougui drink group (group B,10 rats) and normal group (group C,5 rats)with random number table. Endotoxin were injected into abdominal cavity of rats in group A and B for 2 days, methylprednisolone sodium succinate were injected by gluteus for twice a week continued for 6 weeks; group B were gavaged by Yougui drink (veryday for 8 weeks; group C did not do any processing. All rats were killed on the 10th weeks,m icro CT were used to scan femoral head in vitro and preventive effect of Yougui drink (n femoral head necrosis in rats.
RESULTSThere was statistical significance in BMD, BV/TV, Tb.N, Tb, Th, Thb, Sp, BS/TV and DA but no significance in SMI between group A and B. Comparison between A and C, there was significant meaning in BMD, BV/TV, Tb.N, Tb, Th, Tb, Sp, BS/TV, DA and SMI.
CONCLUSIONYougui drink on femoral head necrosis in rats under micro CT has preventive effect from BMD BV/TV, Tb.N, Tb, Th, Tb, Sp, BS/TV and DA.