Clinical and laboratory studies of 11 acute myeloid leukemia patients with t(7;11) (p15;p15) translocation.
- Author:
Si-Ping WANG
1
;
Shu-Ning WEI
;
Jun-Yuan QI
;
Xu-Ping LIU
;
Hong-Le YANG
;
Jia-Wei ZHAO
;
Gang AN
;
Jian-Xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 7; Female; Humans; Karyotype; Leukemia, Myeloid, Acute; diagnosis; genetics; Male; Middle Aged; Prognosis; Retrospective Studies; Translocation, Genetic; Young Adult; fms-Like Tyrosine Kinase 3; genetics
- From: Chinese Journal of Hematology 2011;32(8):533-536
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate clinical and laboratory characteristics of acute myeloid leukemia (AML) patients with t(7;11)(p15;p15).
METHODSEleven patients with t(7;11)(p15;p15) were retrospectively reviewed involved in cell morphology, immunophenotype, cytogenetics as well as clinical features and prognosis.
RESULTSEight patients out of the eleven were female, six patients were AML-M2a, two M4, two M5, and one M6. All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively. Karyotypes of all the patients were t(7;11) (p115;p15), additional trisomy 8 were found in only one patient. FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD. Two patients were alive, and one lost to followed up, while the rest of eight were dead.
CONCLUSIONThe t(7;11) (p15;p15) abnormalities is one of rare chromosomal translocation in patients with AML. AML patients with t(7;11) (p15;p15) have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.
