The type I insulin-like growth factor receptor highly expressed in clonal cells of myelodysplastic syndromes.
- Author:
Qi HE
1
;
Xiao LI
;
Zheng ZHANG
;
Qing-xia ZHANG
;
Lian-ping YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Clone Cells; metabolism; pathology; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; metabolism; pathology; Receptor, IGF Type 1; metabolism; Young Adult
- From: Chinese Journal of Hematology 2011;32(11):744-747
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo probe the expression level of insulin-like growth factor-I receptor (IGF-IR) in malignant clone cells of myelodysplastic syndromes (MDS).
METHODThe combination of fluorescence in situ hybridization (FISH) and immunochemistry (alkaline phosphatase anti-alkaline phosphatase, APAAP) was used to detect the expression of IGF-IR in the bone marrow cells of 40 MDS patients with abnormal karyotypes.
RESULTSThe average IGF-IR expression level on the clone cells \[(84.5 ± 14.2)%\] from the MDS cases was markedly elevated compared to the corresponding level on normal cells \[(11.4 ± 12.1)%\]. And the percentages of malignant clone cells in all 40 MDS cases were significantly correlated with the relevant percentages of IGF-IR positive nucleated cells (r = 0.929, P < 0.01).
CONCLUSIONSIGF-IR might be taken as a marker of clone cells in MDS for its trait to malignant proliferation.
